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Sometimes there are vital synergistic relationships between these various serotonin boosting substances.There are several co-factors required to make the most commonly used serotonin supplements do their job.Unfortunately, this supplement’s usefulness for depression may be more hype than substance.A review of 108 studies on 5-HTP revealed there is still no definitive evidence that it helps depression (9). An Ongoing Debate: There’s an ongoing discussion in the natural health community whether it’s better to take tryptophan or 5-HTP to increase serotonin levels.However, tryptophan supplements can increase brain serotonin even though eating foods containing tryptophan does not (5).Tryptophan supplements fell out of favor when a contaminated batch from Japan caused thousands to fall ill in the 1980s.
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While it’s increasing serotonin, it’s depleting other neurotransmitters like dopamine.
Within a few months, this inevitably causes a cascade of negative side effects (10). Datis Kharrazian, author of , lists these co-factors as needed for the synthesis of either tryptophan or 5-HTP to serotonin — vitamins B3, B6, and B12, folic acid, and magnesium.
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Serotonin supplements like specific amino acids, vitamins, minerals and herbs increase serotonin levels helping depression and other brain-related disorders.
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Conversely, there are times when these supplements can react adversely with medications or other serotonin supplements, and you need to know about those, too.